The results of research headed by a team in the lab of Michael Sigal, MD, at the Max Delbrück Center and Charité—Universitätsmedizin Berlin, have shed new light on the role of the p53 tumor ...

The study was published in the journal Science Advances. ‘Researchers have identified the role of the p53 gene in #ulcerativecolitis, paving the way for potential new treatments to prevent # ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in ...

By Dr. Sushama R. Chaphalkar, PhD. The fragile structure of p53 gene reveals why this crucial cancer defense is so easily ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité—Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study ...

We confirmed mutations by direct DNA sequencing. Monoclonal anti-p73 antibodies ER15, ER13 and GC15 were described 3. We used anti-p53 PAb1801 (Ab-2) mouse monoclonal antibody (Oncogene-Science ...

In a potential advance for melanoma patients, researchers at ChristianaCare's Gene Editing Institute have used CRISPR gene editing tools to disable a gene mutation often seen in aggressive forms ...

The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of studies ...

It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

Presentation Details: Title: CLSP-1025, a novel bispecific T cell engager targeting a p53 R175H mutant peptide ... that target tumor-specific oncogenic driver mutations common across hard-to ...

germline Li-Fraumeni mutations and germline p53 polymorphisms. The tumour-associated mutations in sporadic cancers arise in somatic cells, both spontaneously and as a consequence of DNA damage.