Cooper Flagg's health is the biggest storyline in the East Region as top-seeded Duke awaits the return of its freshman sensation. The Blue Devils beat North Carolina and Louisville in the ACC Tournament without the ACC Player of the Year,

FOX Sports' John Fanta breaks down the East Region of the NCAA Tournament, including must-see players, first-round upsets and his pick to come out of the region.

Duke is the tournament’s betting favorite thanks to Flagg, the projected No. 1 overall pick in the upcoming NBA draft, and a couple more first-round prospects. The Blue Devils went 19-1 in ACC play and finished the season with the nation’s largest average margin of victory (20.8 points per game). Jon Scheyer’s group is rolling.