eLife2h
Beta Cells: Opportunity makes a hub or a leader
Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.
eLife16h
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
eLife1d
Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis
This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...
eLife2d
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...
eLife4d
Mapping HIV-1 RNA Structure, Homodimers, Long-Range Interactions and persistent domains by HiCapR
Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...
eLife4d
AI-enabled Alkaline-resistant Evolution of Protein to Apply in Mass Production
During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...
eLife4d
Mesoscale functional architecture in medial posterior parietal cortex
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This study examined the functional organization of the mouse ...
eLife4d
Orexin population activity precisely reflects net body movement across behavioral and metabolic states
This important study shows that the activity of hypothalamic hypocretin/orexin neurons (HONs) correlates with body movement over multiple behaviors. Sophisticated techniques and analyses showcase this ...
eLife5d
Intrinsic bioenergetic adaptations compensate for reduced mitochondrial content in HER2-driven mammary tumors
It is now recognized that mitochondria play a crucial role in tumorigenesis, however, it has become clear that tumor metabolism varies significantly between cancer types. The failure of recent ...
eLife5d
Multi-omics investigation of spontaneous T2DM macaque reveals gut microbiota promote T2DM by up-regulating the absorption of excess palmitic acid
Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, China Sichuan Key Laboratory of Development and Application of ...
eLife5d
Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions
Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States Siteman Cancer Center, Washington University School of Medicine, St Louis, United ...