Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Arthritis was induced in mice exposed to high blood levels of homocysteine. Hyper-homocysteinemia arthritic animals develop diastolic dysfunction (the left ventricle does not dilate properly) with ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

Fungal infections and autoimmunity share a complex, bidirectional relationship that significantly impacts patient outcomes. Emerging evidence highlights how fungal pathogens contribute to autoimmune ...

The solute carrier 17 (SLC17) family contains anion transporters that accumulate neurotransmitters in secretory vesicles, remove carboxylated monosaccharides from lysosomes, or extrude organic anions ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

In this study, we provide a detailed molecular analysis of the KMN subunit Kre28 Zwint. We identified a conserved Zwint helix in Kre28 whose lack leads to fatal chromosome segregation defects when ...

The ER membrane protein SELENOT has been previously suggested to be neuroprotective, but its contribution to neuronal pathophysiology has not been thoroughly investigated. This study reports that ...

Corneal diseases can cause severe visual impairment and even blindness, which have been linked to the interruption of corneal epithelial homeostasis. However, the underlying molecular mechanisms are ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

The endoplasmic reticulum (ER) of the eukaryotic cell is the major site of lipid and membrane protein synthesis, and it acts as a hub for intracellular communication. This organelle extends from the ...

Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain ...